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We report a case of an acute ST-segment elevation myocardial infarction in a affected person with conventional cardiac danger elements using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient additionally had polycythemia, doubtless secondary to high-dose testosterone. The patient underwent successful percutaneous intervention of the best coronary artery. Physicians and sufferers should be conscious of the medical penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a element of endothelial dysfunction has been proposed, which may contribute to irregular vessel reactivity.
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However, testosterone in physiologic doses may even be helpful in patients with angina , have higher ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood flow in males with established coronary artery disease . Therefore, an interplay of endogenous components of the patient’s threat profile in addition to the testosterone dosing may be issues of whether or not antagonistic events occur. Erythrocytosis has been reported as a possible impact of testosterone, which could be beneficial in patients with anemia.
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Patients additionally may be taking concomitant stimulants, corresponding to ephedra, which may confound data and the potential for antagonistic occasions. It is likely that the frequency of cardiac occasions is underreported within the medical literature. Moreover, testosterone has been used within the remedy of lowered muscle mass and bone density in addition to anemia. The position testosterone may play in the development of heart problems has more and more turn into the topic of current curiosity . Supraphysiologic doses of anabolic-androgenic steroids , which embrace more than 30 pure and synthetic derivatives of testosterone, might cause a large spectrum of scientific sequalae. Supplemental or physiologic doses of testosterone have noticed expanded use in medical apply recently. Other frequent potential antagonistic results embody infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .
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